The aim of this continuing education course is to bring up-to-date reviews on the environment, tools and paradigms of toxicologic pathology. It aims to highlight current issues and trends in drug safety and risk assessment through important examples of major target organs and mechanisms of toxicity. The course content and program have been designed to suit the needs of veterinary/toxicologic pathologists and toxicologists in practice as well as residents in pathology who are preparing for ECVP/ACVP examinations. As every year, the organizing committee will invite internationally-known experts from industry and academia to share their experience at this symposium. The course will be taught in English (No simultaneous translation to any language will be available).

Program highlights

  • The Regulatory Environment of Toxicological Studies
  • Interpretation of Results & Risk Assessment
  • Metabolism & Pharmacokinetics of Xenobiotics
  • Evaluation of Vaccine Safety
  • Pathology of the Liver
  • Current Paradigms in Immunotoxicity Testing
  • Inhalation Studies
  • Molecular Biology: New Tools For the Toxcicological Pathologist
  • Toxicologic Pathology of the Male & Female Reproductive Systems
  • Pathology of the Cardiovascular System
  • Drug-Induced Vascular Injury: Pathogenesis & Potential Biomarkers
  • Drug Toxicity Profiles: Nucleoside Analogs, PPARs

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The Regulatory Environment of Toxicological Studies
Jeffery ENGELHARDT, Amgen, CA (USA)
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Metabolism of Xenobiotics
Antoine DESLANDES, Sanofi-Aventis, Paris (France)
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Interpretation of Toxicology Results & Risk Assessment Jeffery ENGELHARDT, Amgen, CA (USA)
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Drug Toxicity Profile of PPARs
Thomas LEMARCHAND, CIT, Evreux (France)
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Pathology of the Liver
Shashi K. RAMAIAH, Texas A&M University, TX (USA)
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Pathology of the Liver (continued)
Shashi K. RAMAIAH, Texas A&M University, TX (USA)
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Species Differences, Structure and Function of the Immune System
Patrick HALEY, Incyte, DE (USA)
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Drug-Induced Lesions of the Immune System
Patrick HALEY, Incyte, DE (USA)
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Drug Toxicity Profiles of Nucleoside Analogs
Jeffery ENGELHARDT, Amgen, CA (USA)
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Inhalation Toxicity Studies
Martin ROSENBRUCH, Bayer HealthCare AG, Wuppertal (Germany)
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Inhalation Toxicity Studies (continued)
Martin ROSENBRUCH, Bayer HealthCare AG, Wuppertal (Germany)
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Molecular Biology New Tools For the Toxicological Pathologist
Shashi K. RAMAIAH, Texas A&M University, TX (USA)
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Evaluation of Vaccine Safety
François VERDIER, Sanofi-Pasteur, Lyon (France) Course dinner
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Toxicologic Pathology of the Male Reproductive System (PART I)
Dianne CREASY, Huntingdon Life Sciences, NJ (USA)
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Toxicologic Pathology of the Male Reproductive System (PART II)
Dianne CREASY, Huntingdon Life Sciences, NJ (USA)
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Drug-Induced Cardiac & Vascular Injury: Pathogenesis & Potential Biomarkers
Heath THOMAS, GlaxoSmithKline, PA (USA)
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Drug-Induced Cardiac & Vascular Injury: Pathogenesis and Potential Biomarkers (continued)
Heath THOMAS, GlaxoSmithKline, PA (USA)
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Toxicologic Pathology of the Female Reproductive System (PART I)
Dianne CREASY, Huntingdon Life Sciences, NJ (USA)
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Toxicologic Pathology of the Female Reproductive System (PART II)
Dianne CREASY, Huntingdon Life Sciences, NJ (USA)
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Organizing committee


  • Pr. Yan CHEREL, Veterinary School of Nantes, Nantes (France)
  • Dr. Dianne M. CREASY, Huntingdon Life Sciences, East Millstone (USA)
  • Dr. Laurence FIETTE, Institut Pasteur, Paris (France)
  • Dr. Mohamed SLAOUI, Sanofi-Aventis, Paris (France)
  • Pr. Monique WYERS, Veterinary School of Nantes, Nantes (France)